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In the second step, we further analyzed gender-related differences depending on the current smoking status of smokers and ex-smokers compared to non-smokers. PLoS Med 3: Female smokers and ex-smokers show higher activation in the bilateral superior frontal gyrus and ACC. Recent neuroimaging research suggests sex-related brain differences in smoking addiction. To investigate more specifically gender-related differences in an addicted population, we contrasted the smokers group with non-smokers.

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Fifty-one subjects were recruited by word of mouth and local advertising. Support Center Support Center. Although gender effects during nicotine addiction are suggested, none of the previous studies contrasted male and female smokers to a non-smoking group to control for the effects of stimulus administration. In the second step, we further analyzed gender-related differences depending on the current smoking status of smokers and ex-smokers compared to non-smokers. No use, distribution or reproduction is permitted which does not comply with these terms. In fact the results of the analyses of craving are confounded by group attribution smokers already have higher craving. Therefore, we agree with the interpretation given by McClernon, suggesting that women and men engage different neural circuits in the processing of craving cues that lead ultimately to similar levels of subjective craving.

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